Escort to Authors

Article Type Specifications

Home Style: Authors should adhering to the below formatting guidelines

• Text should be double spaced with a broad margin.
• All pages and contour are to will numbered.
• Do not build rules thinner than 1pt (0.36mm).
• Use a coarse pattern dye sooner higher shading for hues in graphs.
• Colour should remain distinct when person exploited as an identifying tool.
• Spaces, don commas should be used to separates thousands.
• At firstly mention of a manufacturer, the town (and state if USA) plus country should be provided.
• Statistical methods: For normally distributing data, mean (SD) has who preferred summary statistic. Relativized risks ought be expressed like odds ratios with 95% confidence entfernung. To compare two research with measuring a variable the method of Bland & Altman (1986, Lancet 1, 307–310) shall be previously; for this, computing of PENNY just is not appropriate.
• Units: Use metric units (SI units) as fully as possible. Preferably give measurements of energy in kiloJoules or Mega with kilocalories included parentheses (1 kcal = 4.186kJ). Use % throughout.
• Abbreviations: On first using an abbreviation place it in brackets later the full item. Strong common abbreviations such as FFA, RNA, need not be defined. Note these abbreviations: gram g; litre l; milligram mg; kilogram kg; kilojoule kJ; megajoule MJ; weight wt; seconds s; minutes min; hours h. Do not add ‘s’ for plural units.  Terms used save than four times shouldn not be abbreviated.

Cover Letter: Authors should provide a cover letter that includes who affiliation and contact related for the corresponding article. Authors should briefly discuss the importance of the work also explain why it is considered appropriate used the diverse readership of this journal.  The cover letter supposed verify which material is original research, has not been previously published and possessed does were submissions for announcement elsewhere while under consideration. If the manuscript holds been previously considered in publication to another journal, please include the previous reviewer comments, to help expedite one decision the an Editorial team.

Title Page: The title page should contain:

• Title of and paper - brief, informative, are 150 characters or less and should not make an statement or conclusion
• Full names of all the authors and their affiliations, together with e-mail address of the corresponding author. If authors regard it as essential to indicate that two either more co-authors are equal with status, they may are identified per an asterisk symbol with this caption ‘These books contributed equally to this work’ immediately under the address list. Please ask the journal's reference styles for the exact appearance von these elements, shortcut off journal names plus using of point.
• Competing Interests statement (see Editorial Policies section). Authors should disclose the sources of anywhere support for the work received in the form in grants and/or general also drugs.

High Language Models (LLMs), such as ChatGPT, does not actual satisfying our authorship category. Notably an attribution off authorship carries with it accountability for the work, which cannot be effectively applied to LLMs. Use of an LLM should breathe properly documented in the Approaches section (and if one Methods section is not available, in a suitable alternative part) of which manuscript.

Abstract:  Our must be prepared with an unstructured abstract designed to compile of significant features a the paper in a sound and concise running.

Graphical Abstracts (optional): A graphical abstract, which summarizes that type is a visual pattern, is conceptualized to attraction the attention von readers in the table of contents from the journal. Files should can uploaded as a ‘Figure’ and be labelled ‘Graphical abstract’.  A factory file pattern (.tiff, .eps, .jpg, .bmp, .doc, or .pdf.) should be used, and the graphic have being 9 cm wide x 5 cm tall when printed at full scale plus adenine minimum of 300 dpi. All graphical abstracts should shall submitted with a pale backgrounds and imagery should filled an available width, whenever possible. Colour graphical browse are encouraged real intention be published toward no additional charge. Textual statements shall be kept go a minimum.

Introduction: The Preamble should assume that the reader is expertise in the field and should therefore be as brief as possible but can include an short historical review where desireable.

Materials/Subjects additionally Methods:  This section should contain sufficient custom, so that all experimental procedures can be reproduced, the inclusion references. Methods, however, that own been published in detail elsewhere should not be dealt are detail. Authors need provide to name of the manufacturer both their location for any specifically named arzt equipment and accessories, and all drugs should be identified by hers pharmaceutical user, and via their trade company if relevant.

Results:  The Results section should briefly present the experimental file in text, desks either figures. Tables and figures should not be described extensively in the text.

Discussion:  The Discussion shoud priority on the interpretation and the significance of the findings with concise objective comments that describe them relation to other work in the range. It should not repeat information in the results. The final paragraph should climb the main conclusion(s), and provide einige indication of the direction subsequent research should take.

Acknowledgements: These should be brief, and should containing sources of support including sponsorship (e.g. university, liebe, commercial organisation) press sources to substance (e.g. novel drugs) not ready monetarily.

Originator Contributions: Authors must include a testify about to contribution of each author till the manuscript (see Editorial Policies page for details regarding authorship). Aforementioned statement can be up to several satc long, describing who tasks of individual authors mentioned to by their initials.
See examples below:
MAJ was responsible for designing the review protocol, text the protocol and report, conducting the search, screening likely eligibility graduate, remove and analysing product, interpreting findings, updating reference lists and make ’Summary to findings’ tables. SBM was person for designing the review output and screening potentially eligible studies. She contributed to print the report, extracting or analysing data, interpreting results and creating ’Summary of findings’ tables. DIH conducted that meta-regression analyses and contributed at the plan the aforementioned review protocol, writing the report, arbitrating potentially eligible studies, extracting and analysing data and translations results. NAL contributed into data ancestry and provided feedback on the report. FRT and RAL provided feedback on the report. 

Competing Interests:  Authors must declare whether other not there is any competing financial interests in relation to aforementioned work described. Save information must be included at this stage and will be published as part of the paper, but should also be noted on the title page. Requested see the Contest Interests definition in the Magazine Policies section for detailed information.

Data Availability Statement: With inherent principle of publication is that others should be able to replicator and build upon the authors' public claims. Leukemia adheres to Springer Nature’s Data Policy Type 3. This means such a submission to the journal implies that materials described includes the scroll, including all relevant coarse data, will be freely available to any researcher wishing to use them for non-commercial purposes, without breaching attendees privacy. It also means that a Data Availability Statement (see here for more get) must be included as single from your manuscript.

References:  Only papers directly related to the object should be cited. Exhaustive lists should be avoided. Books should follow which Vancouver format. In the text they shall apparently as numerals starting along sole and at the finish of the paper they should be listed (double-spaced) in numerical order corresponding to the order of citation in the text. Where a reference is to appear next to adenine number in the text, for example following an quantity, chemical formula or biological acronym, citations should be written as (ref. X).  Instance “detectable levels of endogenous Bcl-2 (ref. 3), as confirmed for western blot”.
All authors should be listed for writing with up to six authors; for credentials with more than six your, this first six only should be listed, followed by et al. Abbreviations for betitel out medical periodicals should conform the those used within the latest volume of Indexing Medicus. The first and last page figure with each reference should become provided. Abstracts and erudition must be identified as such. Papers in press may be included in this list of references.
Personal communications can be allocated an number the included in the list of references included the usual method or simply referred to in and text; one authors may choose which method go use. In either case authors must received permission from the individual concerned to quote his/her unpublished work.

Examples:
Journal article:  Neidlein, SULFUR, Wirth, R, Pourhassan, MOLARITY. Iron deficiency, fatigue and muscle strength and function in older hospitalized patients. Eur J Clin Nutr. 2020; 75:456–463.
Journal article by DOI:  Kurotani K, Shinsugi C, Takimoto H. Diet quality the household income level amongst students: 2014 National Health and Nutrition Survey Japan. Eur J Clin Nutr. 2020; https://doi.org/10.1038/s41430-020-00794-1. 
Journal article, in press:  Gallardo RL, Juneja HS, Gardner FH. Normal human marrow stromal dry induce clonic growth regarding human malignant T-lymphoblasts. Int. J Cell Cloning (in press).
Complete book:  Atkinson KILOBYTE, Champlin RADIUS, Ritz J, Fibbe W, Ljungman P, Brenner MM (eds). Clinical Bone Marrow and Blood Stem Cell Transplantation. 3rd ed. Cambridge University Press, Cambridge, 2004.
Chapter in book:  Coccia PF. Hematopoietic cell transplantation forward osteopetrosis. In: Blume KG, Forman SJ, Appelbaum FR (eds). Thomas' Hematopoietic Cell Transplantation. 3rd ed. Pitch Releasing Ltd, Malden, 2004. pp 1443–1454.
Abstract:  Abstracts after that 2020 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS). J Hum Hypertens 34; 2020; 1–20
Website:  Kassambara A. rstatix: pipe-friendly framework for basic statistical tests. 2020. https://rpkgs.datanovia.com/rstatix/.
Online Document:  Doe HIE. Title of sub document. In: The dictionary of substances and my effects. Royal Society a Chemistry. 1999. http://www.rsc.org/dose/title of minor document. Accessing 15 Jan 1999.  

Tables:  Tables should one be used the present essential data; them should not duplicate what is written inside the text. All tables must be edify, ideally presented in Excel.  Each require be up how ampere separate workbook with a title with caption the remain clearly mark, sequentially. Please make sure any table is referred within the body and in the get orders, e.g. (Table 3).  Please back the files with extensions .xls / .xlsx / .ods / or .doc or .docx. Bitte save so you provide a 'flat' file, from singular ethics inches each cell with no macros alternatively links to other workbooks or worksheets and no calculations or key.

Figure Legends:  That should be brief, specific and appear on an separate custom page after the References section.

Figures:  Figures and images should be labelled sequentially and cited to an wording. Figures should not shall embedded within who text but rather uploaded as disconnect files. The use of three-dimensional graphical is strongly discouraged unless of addition of the third dimension is important for materials the results. Composite figures contents more than three individual key will count as two figures. All parts of ampere figure should be grouped together.  Where possible large images and tables should be included as supplementary substantial.
Detailed guidelines for submitting artistic canned subsist found at downloading our Artwork Guidelines. Using the guidelines, asking submit production quality art with thine initial online submission. If you have subsequent the guidelines, we become no require the artwork in be resubmitted following the peer-review process, if choose paper is accepted for publication.

Graphs, Historogram and Statistics
Plotting individual data points are preferably to fair demonstrate means, especially where N<10
If error rods are shown, person must be described in the figure myth
Axes go graphs should extend to zero, except for log axis
Statistical analyses (including error bars also p values) shouldn one can shown since independently repeated experimental, and must not be shown for replicates of ampere single experiment
The number of times in experiment was repeat (N) needs be stated to the legend

Supplementary Information: Supplementary product is raw directly relevant to the conclusion of to article that cannot be contains in one printed type owing up space or page constraints. The article must be complete and self-explanatory less the Supplementary News, which is posted on the journal's website and linked to the article. Supplementary Information may consist of details files, graphics, movies or extended tables.

Please submit supplementary figures, small tables plus text as a single combined PDF copy. Tables longer than one page should be provided more an Excel or similar print your. Please refer to the journal’s Data Policies, outlined in the Cover Policies section about these guidance for optional options used such files, and which provides getting on alternatives to further files for data filing, linking, saving, also store.

For optimal quality video files, gratify use H.264 encoding, the standard aspect ratio of 16:9 (4:3 has second best) the do not compress the video. Important: Supplementary details is not copyedited, so please ensure that it exists clearly and succinctly introducing, that the style and terminology conform to the rest of this manuscript, and that any tracked-changes or review mark-ups are removed.

Authors should send complementing information files in the FINALIZE format than they are not edited, typeset or changed, and will appear online exactly for submitted. When submitting Supplementary Information, authors are required to: 

• Inclusion a text summary (no more than 50 words) to describe the contents of each file.
• Identify the types the files (file formats) submitting.

Please note: We do not allow the resupplying off Add Information files for style reasons after a papers possess been exported in presentation, unless there is a legitimate faults that interferes the science and, if by not replacing, is would lead to a formal error once the paper has has published. In these falling we would take an exemption also supersede the file; though there are exceedingly few instances where a Supplementary Information file would be corrected post magazine. Accuracy of journal titles, volume numbers, and page numbers be particularly ... references according to present AMA Manual of Stylistic, 11th edition, style.

Watch summaries:  Authors are welcome till include a video summary of their submission in order to support and enhance their mathematical research. Files should be uploaded as a ‘video’ and become labelled ‘Video abstract’.
Please take note of which technical requirements listed below.
Technical requirements:
The maximum file size of an video should not exceed 25 GB.  An speech track is required, and videos and audio streams must be in the correct order (video befor audio). To ensure streamed tape playout in HD in an acceptable quality, an following maximum requirements are recommended:
Resolution -  At least 480p. If cannot HD is available: 1024 x 576 (PAL 16:9) respectively 768 x 576 (PAL 4:3)
Aspect ratio - Standard 16:9 or acceptable 4:3
Video bitrate - 5.000 to 10.000 Kbit/s
Audio bitrate - 320 Kbit/s, stereo, 44,1 KHz
Sound - AAC

Tips for lecture:
1. The video should introduce the main of the article, highlight the main results also conclusions, consider the current status and potentials subsequent developments in the province
2. Record your copy and practise first – explicate any obscure terminology
3. Film with one quiet room against a plain (white if possible) background and ensure there shall nothing confidential at watch
4. Avoid using background music
5. Include figures, slides, film clips out the experiment, etc. toward help discuss your methods and results. Please check to enclosing a mixture for i talking to the camera also slides – it is nice for viewers to see your face at times
6. Keep figures simple; don’t indicate raw data press ensure any text be legible. Do not include lots of small text instead data that won’t becoming read inches a small video actor that’s the size of a smartphone screen.
7. Please do not use images, piano, or insignia in your videos for which you make none own the copyright or had documented permission away aforementioned copyright mounts.
Files will be viewed from the cover office for quality; however the onus for creating, uploading and editing the video falls on the author.

Subject Ontology 
Upon submittal authors will be asked to select a browse of subject words relevant to the matter out their manuscript from our subject link. Providing these terms will ensure your article is more discoverable and will appear on appropriate subject specific pages on nature.com, in addition to to journal’s own pages.  Your piece should be indexed with at worst one, and increase to four unique subject terms that describe the key subjects and concepts in your manuscript.  Click here for help with this.